Vpr protein of human immunodeficiency virus type 1 binds to 14-3-3 proteins and facilitates complex formation with Cdc25C: implications for cell cycle arrest.

@article{Kino2005VprPO,
  title={Vpr protein of human immunodeficiency virus type 1 binds to 14-3-3 proteins and facilitates complex formation with Cdc25C: implications for cell cycle arrest.},
  author={Tomoshige Kino and Alexander Gragerov and Antonio Valent{\'i}n and Maria Tsopanomihalou and Galina Ilyina-Gragerova and Rebecca Ann Erwin-Cohen and George P. Chrousos and George N Pavlakis},
  journal={Journal of virology},
  year={2005},
  volume={79 5},
  pages={
          2780-7
        }
}
Vpr and selected mutants were used in a Saccharomyces cerevisiae two-hybrid screen to identify cellular interactors. We found Vpr interacted with 14-3-3 proteins, a family regulating a multitude of proteins in the cell. Vpr mutant R80A, which is inactive in cell cycle arrest, did not interact with 14-3-3. 14-3-3 proteins regulate the G(2)/M transition by inactivating Cdc25C phosphatase via binding to the phosphorylated serine residue at position 216 of Cdc25C. 14-3-3 overexpression in human… CONTINUE READING
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