Vpr-induced cell cycle arrest is conserved among primate lentiviruses.

@article{Planelles1996VprinducedCC,
  title={Vpr-induced cell cycle arrest is conserved among primate lentiviruses.},
  author={Vicente Planelles and Jonathan Jowett and Q. X. Li and Yan Xie and B Hahn and Irvin S. Y. Chen},
  journal={Journal of virology},
  year={1996},
  volume={70 4},
  pages={2516-24}
}
We previously reported that expression of human immunodeficiency virus type 1 strain NL4-3 (HIV-1(NL4-3))vpr causes cells to arrest in the G2 phase of the cell cycle. We examined the induction of cell cycle arrest by other HIV-1 isolates and by primary lentiviruses other than HIV-1. We demonstrate that the vpr genes from tissue culture-adapted or primary isolates of HIV-1 are capable of inducing G2 arrest. In addition, we demonstrate that induction of cell cycle arrest is a conserved function… CONTINUE READING

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