Voxelwise Meta-Analysis of Gray Matter Abnormalities in Bipolar Disorder

@article{Bora2010VoxelwiseMO,
  title={Voxelwise Meta-Analysis of Gray Matter Abnormalities in Bipolar Disorder},
  author={E. Bora and A. Fornito and M. Y{\"u}cel and C. Pantelis},
  journal={Biological Psychiatry},
  year={2010},
  volume={67},
  pages={1097-1105}
}
BACKGROUND We conducted a meta-analysis of gray matter abnormalities in bipolar disorder (BD) using voxel-based morphometry studies to help clarify the structural abnormalities underpinning this condition. METHODS A systematic review was conducted for voxel-based morphometry studies of patients with BD. Meta-analyses of gray matter differences between BD and control subjects were undertaken using "signed differential mapping," a novel method that, in contrast to previously used techniques… Expand
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References

SHOWING 1-10 OF 77 REFERENCES
Regional Gray Matter Changes in Bipolar Disorder: A Voxel-Based Morphometric Study
TLDR
Evidence of gray matter volume abnormalities in adults with bipolar I disorder is presented, which suggests a neurobiological basis for clinical heterogeneity and posits the possibility of trait deficits. Expand
Changes in Gray Matter Volume in Patients with Bipolar Disorder
TLDR
Suggestions that neurofunctional deficits are related to structural brain abnormalities in patients with bipolar disorder are supported and the increased gray matter observed in several regions suggests that some affected areas may demonstrate volumetric expansion, at least in some patient populations. Expand
Voxel-wise meta-analysis of grey matter changes in obsessive-compulsive disorder.
  • J. Radua, D. Mataix-Cols
  • Psychology, Medicine
  • The British journal of psychiatry : the journal of mental science
  • 2009
TLDR
The results support a dorsal prefrontal-striatal model of the disorder and raise the question of whether functional alterations in other brain regions commonly associated with OCD, such as the orbitofrontal cortex, may reflect secondary compensatory strategies. Expand
No change to grey and white matter volumes in bipolar I disorder patients
TLDR
The aim of this VBM study was to investigate grey and white matter volumes in a large sample of patients with bipolar I disorder and healthy control subjects and was not able to identify core regions of structural abnormalities in bipolar disorder. Expand
Voxel-Based Study of Structural Changes in First-Episode Patients with Bipolar Disorder
TLDR
Structural changes are absent from VLPFC early in the course of bipolar disorder, suggesting that dysfunctional neuronal proliferation or pruning may occur in bipolar patients. Expand
Prefrontal-temporal gray matter deficits in bipolar disorder patients with persecutory delusions.
TLDR
The findings suggest that stratification based solely on psychotic symptoms is insufficient for the differentiation of BD into biologically meaningful subgroups, but also question the pathophysiological validity of the dichotomy in classification between schizophrenia and BD. Expand
Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry
TLDR
Embedded morphometric abnormalities in the posterior cingulate, superior temporal and lateral orbital cortices in BD support the hypothesis that the extended network of neuroanatomical structures subserving visceromotor regulation contains structural alterations in BD. Expand
Frontotemporal alterations in pediatric bipolar disorder: results of a voxel-based morphometry study.
TLDR
Reductions in amygdala and accumbens volumes are consistent with neuropsychological data on pediatric BPD, which is consistent with data implicating the prefrontal cortex in emotion regulation, a process that is perturbed in BPD. Expand
Voxel-based morphometry in adolescents with bipolar disorder: first results
TLDR
Automated volumetric studies and whole-brain voxel-based morphometry on gray matter revealed significantly greater gray matter volume in central gray matter structures bilaterally in the bipolar group, confirming and extending earlier studies. Expand
Meta-analysis of magnetic resonance imaging brain morphometry studies in bipolar disorder
BACKGROUND Several studies assessing volumetric measurements of regional brain structure in bipolar disorder have been published in recent years, but their results have been inconsistent. Our aim wasExpand
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