Voxel size dependency, reproducibility and sensitivity of an in vivo bone loading estimation algorithm.

@article{Christen2016VoxelSD,
  title={Voxel size dependency, reproducibility and sensitivity of an in vivo bone loading estimation algorithm.},
  author={Patrik Christen and Friederike A. Schulte and Alexander Zwahlen and Bert van Rietbergen and Stephanie Boutroy and Lee Joseph Melton and Shreyasee Amin and Sundeep Khosla and Joerg Goldhahn and Ralph M{\"u}ller},
  journal={Journal of the Royal Society, Interface},
  year={2016},
  volume={13 114},
  pages={20150991}
}
A bone loading estimation algorithm was previously developed that provides in vivo loading conditions required for in vivo bone remodelling simulations. The algorithm derives a bone's loading history from its microstructure as assessed by high-resolution (HR) computed tomography (CT). This reverse engineering approach showed accurate and realistic results based on micro-CT and HR-peripheral quantitative CT images. However, its voxel size dependency, reproducibility and sensitivity still need to… CONTINUE READING