• Chemistry
  • Published 2015

Vortioxetine hydrobromide preparation method

  title={Vortioxetine hydrobromide preparation method},
  author={曲继广 and 刘翠环 and 印杰 and 樊根遥 and 曹柳 and 姜召红 and 吴楠},
The invention provides a vortioxetine hydrobromide preparation method. The vortioxetine hydrobromide preparation method comprises the following steps: a reaction is performed between o-bromoiodobenzene and 2,4-dimethylbenzenethiol in a protonic solvent under the action of a cuprous catalyst, glycol and inorganic base to obtain 2-(2,4-dimethylthiophenyl) bromobenzene (a compound IV); the compound IV in an aprotic solvent is coupled with piperazine under the action of a palladium catalyst, a… CONTINUE READING