Vortioxetine: a New Treatment for Major Depressive Disorder

@article{Connolly2016VortioxetineAN,
  title={Vortioxetine: a New Treatment for Major Depressive Disorder},
  author={K Ryan Connolly and Michael E. Thase},
  journal={Expert Opinion on Pharmacotherapy},
  year={2016},
  volume={17},
  pages={421 - 431}
}
INTRODUCTION Vortioxetine is a structurally novel medication that has recently been approved for treatment of major depressive disorder (MDD. [] Key Method Pre-approval studies were identified as all randomized, placebo-controlled studies of vortioxetine listed on clinicaltrials.gov.

A “Real-World” Chart Review Study of Monotherapy and Adjunctive Vortioxetine in Clinical Practice

Vortioxetine was found to be efficacious with minimal side effects and may improve cognition in depression and has a lower incidence of treatment-emergent sexual dysfunction.

Vortioxetine: A Review in Cognitive Dysfunction in Depression

Vortioxetine is a useful treatment option in patients with MDD where impaired cognitive function is apparent and significantly improved a subjective measure of cognitive function (the Perceived Deficits Questionnaire) and an objective measure of functional capacity (the University of San Diego performance-based skills assessment).

Vortioxetine and Lewy Body Disorders

The use of Vortioxetine for patients with Lewy Body Disorders may present complications due to its effect on neurotransmitter pathways affected by Lewy pathology, as well as its interactions with medications frequently prescribed to that population, including Bupropion and Carbidopa-Levodopa.

Pharmacological and Neuromodulatory Treatments for Panic Disorder: Clinical Trials from 2010 to 2018

The efficacy of tranylcypromine, paroxetine, clonazepam, alprazolam and escitalopram is confirmed, and vortioxetine and TMS, with duration of 4 or more weeks, also seems to be effective.

Vortioxetine: Clinical Pharmacokinetics and Drug Interactions

Vortioxetine is a novel antidepressant with multimodal activity currently approved for the treatment of major depressive disorder. Vortioxetine is orally administered once daily at 5- to 20-mg doses.

Neuroanatomical, Biochemical, and Functional Modifications in Brain Induced by Treatment with Antidepressants.

An overview of structural changes in the brain during depression; different neurobiological theories and novel drug development; strategy of augmentation with combinatorial therapy; receptors and targets of actions of antidepressants; and involvement of key signaling factors in the regulation of depression, pharmacology, metabolism, and the underlying principles involved in displaying how the application of antidepressants modulates the structure and function of the brain are presented.

Paroxetine versus Vortioxetine for Depressive Symptoms in Postmenopausal Transition: A Preliminary Study.

This observational study aims to compare paroxetine and vortioxetine in a sample of patients affected by postmenopausal depression attending the Anxiety and Depression Clinic in terms of efficacy in determining clinical remission (HDRS ≤ 7) and tolerability; improvement of autonomic and cognitive symptoms.

Post-Marketing Safety Profile of Vortioxetine Using a Cluster Analysis and a Disproportionality Analysis of Global Adverse Event Reports

A pattern of co-reported adverse events that is consistent with labelled adverse events for vortioxetine and the safety profile for selective serotonin reuptake inhibitors in general was revealed.

An open-label, flexible dose adaptive study evaluating the efficacy of vortioxetine in subjects with panic disorder

Some support for the use of vortioxetine in the management of panic disorder is provided, with a statistically significant decrease in the occurrence of panic attacks and a moderate improvement in the quality of life.

References

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Effect of Vortioxetine vs. Escitalopram on Sexual Functioning in Adults with Well-Treated Major Depressive Disorder Experiencing SSRI-Induced Sexual Dysfunction.

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The trazodone Contramid formulation was more effective than placebo in major depressive disorder and was well tolerated, including improvements in quality of sleep.
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