Voriconazole concentration in human aqueous humor and plasma during topical or combined topical and systemic administration for fungal keratitis.

@article{Thiel2007VoriconazoleCI,
  title={Voriconazole concentration in human aqueous humor and plasma during topical or combined topical and systemic administration for fungal keratitis.},
  author={Michael Alexander Thiel and Annelies S Zinkernagel and J{\"u}rgen Burhenne and Claude Kaufmann and Walter Emil Haefeli},
  journal={Antimicrobial agents and chemotherapy},
  year={2007},
  volume={51 1},
  pages={
          239-44
        }
}
Voriconazole (VRC) is an antifungal drug that effectively treats keratitis caused by yeasts and molds when administered orally. We retrospectively evaluated clinical outcomes and plasma and aqueous humor drug concentrations in five patients with fungal keratitis and one patient with posttraumatic endophthalmitis who were treated with VRC. VRC was administered either topically (1% eye drops every hour) or orally (400 mg twice a day). Plasma and aqueous humor samples from affected eyes were taken… CONTINUE READING
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