Voriconazole and sirolimus coadministration after allogeneic hematopoietic stem cell transplantation.

@article{Marty2006VoriconazoleAS,
  title={Voriconazole and sirolimus coadministration after allogeneic hematopoietic stem cell transplantation.},
  author={Francisco M Marty and C. M. Mow – Lowry and Corey S Cutler and Bonnie J Campbell and Karen Fiumara and Lindsey Robert Baden and Joseph H Antin},
  journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation},
  year={2006},
  volume={12 5},
  pages={552-9}
}
Sirolimus is increasingly used in transplantation for prevention and treatment of graft-versus-host disease and organ rejection. Voriconazole is contraindicated when used concomitantly with sirolimus because of a substantial increase in sirolimus drug exposure with unadjusted dosing, but voriconazole is also considered the best initial treatment of invasive aspergillosis and other fungal infections. Patients who received voriconazole and sirolimus concomitantly were identified by a review of… CONTINUE READING
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