Voriconazole and fluconazole increase the exposure to oral diazepam

@article{Saari2007VoriconazoleAF,
  title={Voriconazole and fluconazole increase the exposure to oral diazepam},
  author={Teijo I Saari and Kari Laine and Leif Bertilsson and Pertti J Neuvonen and Klaus T. Olkkola},
  journal={European Journal of Clinical Pharmacology},
  year={2007},
  volume={63},
  pages={941-949}
}
We assessed the effect of voriconazole and fluconazole on the pharmacokinetics and pharmacodynamics of diazepam. Twelve healthy volunteers took 5 mg of oral diazepam in a randomised order on three study sessions: without pretreatment, after oral voriconazole 400 mg twice daily on the first day and 200 mg twice daily on the second day, or after oral fluconazole 400 mg on the first day and 200 mg on the second day. Plasma concentrations of diazepam and N-desmethyldiazepam were determined for up… CONTINUE READING
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