Von hippel-lindau: a tumor suppressor links microtubules to ciliogenesis and cancer development.

@article{Kuehn2007VonHA,
  title={Von hippel-lindau: a tumor suppressor links microtubules to ciliogenesis and cancer development.},
  author={E Wolfgang Kuehn and Gerd Walz and Thomas Benzing},
  journal={Cancer research},
  year={2007},
  volume={67 10},
  pages={
          4537-40
        }
}
  • E Wolfgang Kuehn, Gerd Walz, Thomas Benzing
  • Published in Cancer research 2007
  • Biology, Medicine
  • Loss of von Hippel-Lindau (VHL) tumor suppressor gene function occurs in familial and most sporadic renal cell carcinoma. The tumor suppressor role of the protein pVHL is based on its ability to target transcription factors of the hypoxia-inducible factor family for degradation, but other functions of pVHL are less clearly defined. New findings show that pVHL is necessary for cilia formation. pVHL interacts with PAR proteins, a complex that specifies the membrane domains of polarized epithelial… CONTINUE READING

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