Von Willebrand factor-cleaving protease activity and proteolysis of von Willebrand factor in bone marrow transplant-associated thrombotic microangiopathy.

@article{Arai2001VonWF,
  title={Von Willebrand factor-cleaving protease activity and proteolysis of von Willebrand factor in bone marrow transplant-associated thrombotic microangiopathy.},
  author={Sally Arai and Charles Allan and Michael B. Streiff and Grover M. Hutchins and Georgia B. Vogelsang and Han-Mou Tsai},
  journal={The hematology journal : the official journal of the European Haematology Association},
  year={2001},
  volume={2 5},
  pages={292-9}
}
INTRODUCTION Thrombotic microangiopathy (TM) of the fulminant type occurring in patients following bone marrow transplant (BMT) has clinical manifestations that are similar to thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome, but the outcome is generally fatal despite conventional therapy. Idiopathic acquired TTP has been associated with IgG inhibitors to the cleaving protease of von Willebrand factor (vWF) in plasma. In this study, we investigated the role of the vWF… CONTINUE READING

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