Von Willebrand factor and angiogenesis: basic and applied issues

@article{Randi2017VonWF,
  title={Von Willebrand factor and angiogenesis: basic and applied issues},
  author={Anna M. Randi and Michael A. Laffan},
  journal={Journal of Thrombosis and Haemostasis},
  year={2017},
  volume={15},
  pages={13 - 20}
}
  • A. RandiM. Laffan
  • Published 1 January 2017
  • Biology, Medicine
  • Journal of Thrombosis and Haemostasis
The recent discovery that von Willebrand factor (VWF) regulates blood vessel formation has opened a novel perspective on the function of this complex protein. VWF was discovered as a key component of hemostasis, capturing platelets at sites of endothelial damage and synthesized in megakaryocytes and endothelial cells (EC). In recent years, novel functions and binding partners have been identified for VWF. The finding that loss of VWF in EC results in enhanced, possibly dysfunctional… 

von Willebrand factor regulation of blood vessel formation.

The evidence showing that VWF is involved in blood vessel formation is reviewed, the role of VWF high-molecular-weight multimers in regulating angiogenesis is discussed, and the value of studies on BOEC is reviewed in developing a precision medicine approach to validate novel treatments for angiodysplasia in congenital VWD and acquired von Willebrand syndrome.

Impact of Von Willebrand Factor on Bacterial Pathogenesis

In vivo studies using mouse models of bacterial infection and zebrafish larvae provided evidence that the interaction between bacteria and VWF promotes bacterial attachment, coagulation, and thrombus formation, and thereby contributes to the pathophysiology of severe infectious diseases such as infective endocarditis and bacterial sepsis.

Age-Associated Increase in Thrombogenicity and Its Correlation with von Willebrand Factor

This review has aimed to discuss the age-related increase in VWF, its potential mechanisms, and associated coagulopathies as probable consequences.

Circulating Angiogenic Mediators in Patients with Moderate and Severe von Willebrand Disease: A Multicentre Cross-Sectional Study.

Plasma levels of angiogenic factors in patients with various types of VWD were investigated to obtain more insight into the pathogenesis of vascular malformations in these patients and it was hypothesized that VWF deficiency leads to increased circulating levels of other WPB components.

A sticky proposition: The endothelial glycocalyx and von Willebrand factor

It is hypothesized that a similar mechanism may be responsible for the basal secretion of endothelial VWF, whereby the EGC mediates the mechanotransduction of physiological shear stress generated by flowing blood, that in turn contributes to the maintenance of physiological plasma VWF levels.

Role of von Willebrand factor in the angiogenesis of lung adenocarcinoma

The role of VWF in LUAD and its regulatory mechanisms are summarized, andGene expression profiles of LUAD tissues indicate that VWF is differentially expressed inLUAD tissues compared to normal tissues.

Von Willebrand factor contribution to pathophysiology outside of von Willebrand disease

Assessment of contribution of elevated levels of VWF to various thrombotic and nonthrombosis pathological conditions in patients with von Willebrand disease and related conditions is discussed.

New therapies for von Willebrand disease.

  • P. Mannucci
  • Medicine
    Hematology. American Society of Hematology. Education Program
  • 2019
Clinical studies have shown that VWF-only products correct not only the primary VWF deficiency but also the secondary FVIII:C deficiency, and the demonstrated efficacy of these products in various clinical situations and in such a hemostasis-challenging context as surgery testifies to the effectiveness and safety of this approach.

New therapies for von Willebrand disease.

Clinical studies have shown that VWF-only products correct not only the primary VWF deficiency but also the secondary FVIII:C deficiency, and the demonstrated efficacy of these products in various clinical situations and in such a hemostasis-challenging context as surgery testifies to the effectiveness and safety of this approach.

von Willebrand factor deficiency leads to impaired blood flow recovery after ischaemia in mice.

It is concluded that VWF facilitates blood flow recovery in mice and hampers both arteriogenesis and angiogenesis in a hindlimb ischaemia model with impaired leukocytes recruitment and decreased pre-existing collateral density in the absence of VWF.
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Crystallographic studies suggest that VWF level is a useful biomarker for the risk of either bleeding or thrombosis and could be incorporated into a comprehensive approach to treat or prevent these adverse events.

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Circulating and progenitor endothelial cells are abnormal in patients with different types of von Willebrand disease and correlate with markers of angiogenesis

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