Von Willebrand disease: screening, diagnosis, and management.

  title={Von Willebrand disease: screening, diagnosis, and management.},
  author={Ali S Totonchi and Yashar Eshraghi and Daniel O. Beck and Keith R McCrae and Bahman Guyuron},
  journal={Aesthetic surgery journal},
  volume={28 2},
Von Willebrand disease (vWD), a hemorrhagic disorder mimicking a defect in platelet function, is the most commonly inherited coagulopathy, resulting in a deficiency that may prolong bleeding time and increase risk for major bleeding complications during surgery. Von Willebrand factor (vWF) serves a dual role in hemostasis: mediating the initial platelet adhesion to damaged endothelium at the site of vessel injury and stabilizing coagulation factor VIII, an important cofactor in the generation… CONTINUE READING


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