Von Willebrand Factor and Von Willebrand Factor-Cleaving Metalloprotease Activity in Escherichia coli O157:H7-Associated Hemolytic Uremic Syndrome

@article{Tsai2001VonWF,
  title={Von Willebrand Factor and Von Willebrand Factor-Cleaving Metalloprotease Activity in Escherichia coli O157:H7-Associated Hemolytic Uremic Syndrome},
  author={Han-Mou Tsai and W. W. Chandler and Ravindra Sarode and Robert L. Hoffman and Srdjan Jela{\vc}i{\'c} and Rebecca L. Habeeb and Sandra L. Watkins and Craig Wong and Glyn D. Williams and Phillip I Tarr},
  journal={Pediatric Research},
  year={2001},
  volume={49},
  pages={653-659}
}
Hemolytic uremic syndrome (HUS) usually occurs after infection with Shiga toxin-producing bacteria. Thrombotic thrombocytopenic purpura, a disorder with similar clinical manifestations, is associated with deficient activity of a circulating metalloprotease that cleaves von Willebrand factor at the Tyr842-Met843 peptide bond in a shear stress-dependent manner. We analyzed von Willebrand factor-cleaving metalloprotease activity and the status of von Willebrand factor in 16 children who developed… CONTINUE READING
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Pathology of the hemolytic uremic syndrome

  • R Habib
  • 1992
Highly Influential
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