Von Willebrand Factor: Dissociation from Antihemophilic Factor Procoagulant Activity

@article{Weiss1973VonWF,
  title={Von Willebrand Factor: Dissociation from Antihemophilic Factor Procoagulant Activity},
  author={Harvey J. Weiss and Leon W. Hoyer},
  journal={Science},
  year={1973},
  volume={182},
  pages={1149 - 1151}
}
Factor VIII corrects both the clotting defect in hemophilia A and an abnormality of platelet aggregation in von Willebrand's disease. These two activities of factor VIII (antihemophilic factor and von Willebrand factor) are both detected in the void volume when human plasma or cryoprecipitate is chromatographed on Bio-Gel 5M under conditions of isotonic salt concentration. In contrast, antihemophilic factor procoagulant activity is detected with proteins of lower molecular weight when the… 

Studies of the human factor VIII/von Willebrand's factor protein. II. Identification and characterization of the von Willebrand protein.

The purified factor VIII-related protein, previously characterized from normal cryoprecipitate, possesses both procoagulant activity and vWf activity and should be designated the f VIII/vWf protein.

von Willebrand disease.

The factor VIII complex: structure and function.

  • L. Hoyer
  • Medicine
    Progress in clinical and biological research
  • 1981
The information now available permits a preliminary understanding of the molecular defects in the factor VIII deficiency disease.

Recent Advances in Haemophilia and Von Willebrand's Disease 1

The advances in the biochemistry and immunology of AHF have stimulated new considerations of the relationship between that factor and vWf and their molecular biology but the picture is far from clear.

Interaction of factor VIII antigen in hemophilic plasmas with human antibodies to factor VIII.

Data suggest that there are greater antigenic similarities between normal and hemophilic Factor VIII than previously thought.

Factor VIII Procoagulant and Antigen Content of Antihemophilic Factor (AHF) Concentrates

Antihemophilic factor concentrates from six manufacturers were studied for factor VIII procoagulant and antigen content, indicating a significant loss of activity during the fractionation process.

Willebrand Factor and Ristocetin II. RELATIONSHIP BETWEEN WILLEBRAND FACTOR, WILLEBRAND ANTIGEN AND FACTOR‐VIII ACTIVITY

Data from thermo‐stability and dissociation studies favour the hypothesis that factor‐VIII complex consists of two closely related but separate proteins.
...

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