Voluntary running prevents progressive memory decline and increases adult hippocampal neurogenesis and growth factor expression after whole-brain irradiation.

@article{WongGoodrich2010VoluntaryRP,
  title={Voluntary running prevents progressive memory decline and increases adult hippocampal neurogenesis and growth factor expression after whole-brain irradiation.},
  author={Sarah J E Wong-Goodrich and Madeline L. Pfau and Catherine T. Flores and Jennifer A. Fraser and Christina L. Williams and Lee Jones},
  journal={Cancer research},
  year={2010},
  volume={70 22},
  pages={9329-38}
}
Whole-brain irradiation (WBI) therapy produces progressive learning and memory deficits in patients with primary or secondary brain tumors. Exercise enhances memory and adult hippocampal neurogenesis in the intact brain, so we hypothesized that exercise may be an effective treatment to alleviate consequences of WBI. Previous studies using animal models to address this issue have yielded mixed results and have not examined potential molecular mechanisms. We investigated the short- and long-term… CONTINUE READING

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DOI: 10.1158/0008-5472.CAN-10-1854 nial irradiation alters the behaviorally induced immediate-early e arc (activity-regulated cytoskeleton-associated protein). Cancer s 2008;68:9763–70

  • Fa Eff sio Wong-Goodrich
  • Published OnlineFirst September
  • 2010
1 Excerpt

Neurocognitive functioning adult survivors of childhood non - central nervous system cancers

  • J ber
  • atl Cancer Inst
  • 2010

Adult neurogenesis dulates the hippocampus - dependent period of associative fear mory

  • S umatsu, ML Monje, DR Morhardt, R Rola, TD Palmer, Fike
  • Cell
  • 2009

Differential regulation of gliogenesis in the cont of adult hippocampal neurogenesis in mice

  • B iner, G Kronenberg, S Jessberger, Brandt, K Reuter, G mpermann
  • Glia
  • 2009

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