Voluntary resistance running induces increased hippocampal neurogenesis in rats comparable to load-free running.

@article{Lee2013VoluntaryRR,
  title={Voluntary resistance running induces increased hippocampal neurogenesis in rats comparable to load-free running.},
  author={Min chul Lee and Koshiro Inoue and Masahiro Okamoto and Yu Liu and Takashi Matsui and Jang Soo Yook and Hideaki Soya},
  journal={Neuroscience letters},
  year={2013},
  volume={537},
  pages={6-10}
}
Recently, we reported that voluntary resistance wheel running with a resistance of 30% of body weight (RWR), which produces shorter distances but higher work levels, enhances spatial memory associated with hippocampal brain-derived neurotrophic factor (BDNF) signaling compared to wheel running without a load (WR) [17]. We thus hypothesized that RWR promotes adult hippocampal neurogenesis (AHN) as a neuronal substrate underlying this memory improvement. Here we used 10-week-old male Wistar rats… CONTINUE READING
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