Voluntary motor output is altered by spike-timing-dependent changes in the human corticospinal pathway.

@article{Taylor2009VoluntaryMO,
  title={Voluntary motor output is altered by spike-timing-dependent changes in the human corticospinal pathway.},
  author={Janet L Taylor and Peter G. Martin},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 37},
  pages={
          11708-16
        }
}
Repeated pairs of timed presynaptic and postsynaptic potentials cause lasting changes in efficacy of transmission at many synapses. The corticospinal tract is the major pathway controlling voluntary movement in humans, and corticospinal neurons have monosynaptic connections to motoneurons of many muscles. We hypothesized that corticospinal transmission in humans could be altered by delivering, to the corticospinal-motoneuronal synapses, timed pairs of presynaptic volleys (produced by cortical… CONTINUE READING
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In vivo-like conductances limit spike-timing dependent plasticity

  • JY Delgado, NS Desai
  • Soc Neurosci Abstr
  • 2008
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