Voluntary exposure to a toxin: the genetic influence on ethanol consumption

  title={Voluntary exposure to a toxin: the genetic influence on ethanol consumption},
  author={Paula L. Hoffman and Laura M. Saba and Lauren A. Vanderlinden and Boris Tabakoff},
  journal={Mammalian Genome},
Ethyl alcohol is a toxin that, when consumed at high levels, produces organ damage and death. One way to prevent or ameliorate this damage in humans is to reduce the exposure of organs to alcohol by reducing alcohol ingestion. Both the propensity to consume large volumes of alcohol and the susceptibility of human organs to alcohol-induced damage exhibit a strong genetic influence. We have developed an integrative genetic/genomic approach to identify transcriptional networks that predispose… CONTINUE READING
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