Voluntary exercise protects against acute doxorubicin cardiotoxicity in the isolated perfused rat heart.

Abstract

The clinical use of doxorubicin (DOX) is limited by a dose-dependent cardiotoxicity. The purpose of this study was to determine whether voluntary exercise training would confer protection against DOX cardiotoxicity in the isolated perfused rat heart. Female Sprague-Dawley rats were randomly assigned to standard holding cages or cages with running wheels for… (More)

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@article{Chicco2005VoluntaryEP, title={Voluntary exercise protects against acute doxorubicin cardiotoxicity in the isolated perfused rat heart.}, author={Adam J. Chicco and Carole M. Schneider and Reid Hayward}, journal={American journal of physiology. Regulatory, integrative and comparative physiology}, year={2005}, volume={289 2}, pages={R424-R431} }