Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity.

  title={Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity.},
  author={Fernando G{\'o}mez-Pinilla and Zhe Ying and Roland R. Roy and Raffaella Molteni and V. Reggie Edgerton},
  journal={Journal of neurophysiology},
  volume={88 5},
We have investigated potential mechanisms by which exercise can promote changes in neuronal plasticity via modulation of neurotrophins. Rodents were exposed to voluntary wheel running for 3 or 7 days, and their lumbar spinal cord and soleus muscle were assessed for changes in brain-derived neurotrophic factor (BDNF), its signal transduction receptor (trkB), and downstream effectors for the action of BDNF on synaptic plasticity. Exercise increased the expression of BDNF and its receptor… CONTINUE READING
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