Voluntary exercise delays monogenetic obesity and overcomes reproductive dysfunction of the melanocortin-4 receptor knockout mouse.

@article{Irani2005VoluntaryED,
  title={Voluntary exercise delays monogenetic obesity and overcomes reproductive dysfunction of the melanocortin-4 receptor knockout mouse.},
  author={Boman G Irani and Zhimin Xiang and Marcus C Moore and Ronald J. Mandel and Carrie Haskell-Luevano},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={326 3},
  pages={638-44}
}
The melanocortin system is involved in hypothalamic regulation of energy homeostasis. The melanocortin-4 receptor (MC4R) has been linked to both obesity and reproductive dysfunction. Deletion of the MC4R from the mouse genome has resulted in phenotypes including adult onset obesity, hyperphagia, and difficulty in reproducing when homozygote parents are bred. Additionally, polymorphisms of the human MC4R have been identified in morbidly obese children and adults. Herein, we have identified that… CONTINUE READING