Voluntary and forced exercises prevent the development of tolerance to analgesic effects of morphine in rats

@inproceedings{Shokraviyan2014VoluntaryAF,
  title={Voluntary and forced exercises prevent the development of tolerance to analgesic effects of morphine in rats},
  author={Monireh Shokraviyan and Hossein Miladi-Gorji and Gholam Hassan Vaezi},
  booktitle={Iranian journal of basic medical sciences},
  year={2014}
}
OBJECTIVES Morphine is widely used to treat chronic pain. However, its utility is hindered by the development of tolerance to its analgesic effects. Despite the renowned beneficial effects of physical exercise on cognitive functions and signs of morphine withdrawal in morphine-dependent rats, little is known about the roles of voluntary and forced exercises in tolerance to analgesic effect of morphine in rats. MATERIALS AND METHODS In this study, rats were injected with 10 mg/kg of morphine… CONTINUE READING