Voluntary and forced exercise differentially alters the gut microbiome in C57BL/6J mice.

  title={Voluntary and forced exercise differentially alters the gut microbiome in C57BL/6J mice.},
  author={Jacob M. Allen and Margret E. Berg Miller and Brandt D. Pence and Keith Whitlock and Vandana Nehra and H. Rex Gaskins and Bryan A. White and John D. Fryer and Jeffrey A. Woods},
  journal={Journal of applied physiology},
  volume={118 8},
We have previously shown that voluntary wheel running (VWR) attenuates, whereas forced treadmill running (FTR) exacerbates, intestinal inflammation and clinical outcomes in a mouse model of colitis. As the gut microbiome is implicated in colitis, we hypothesized that VWR and FTR would differentially affect the gut microbiome. Mice (9-10/treatment) were randomly assigned to VWR, FTR, or sedentary home cage control (SED) for 6 wk. VWR were given running wheel access, whereas FTR ran on a… 

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