Voluntary and forced exercise differentially alters the gut microbiome in C57BL/6J mice.

@article{Allen2015VoluntaryAF,
  title={Voluntary and forced exercise differentially alters the gut microbiome in C57BL/6J mice.},
  author={Jacob M. Allen and Margret E. Berg Miller and Brandt D. Pence and Keith Whitlock and Vandana Nehra and H. Rex Gaskins and Bryan A. White and John D. Fryer and Jeffrey A. Woods},
  journal={Journal of applied physiology},
  year={2015},
  volume={118 8},
  pages={
          1059-66
        }
}
We have previously shown that voluntary wheel running (VWR) attenuates, whereas forced treadmill running (FTR) exacerbates, intestinal inflammation and clinical outcomes in a mouse model of colitis. As the gut microbiome is implicated in colitis, we hypothesized that VWR and FTR would differentially affect the gut microbiome. Mice (9-10/treatment) were randomly assigned to VWR, FTR, or sedentary home cage control (SED) for 6 wk. VWR were given running wheel access, whereas FTR ran on a… 

Figures and Tables from this paper

Dysbiosis of the gut microbiome impairs mouse skeletal muscle adaptation to exercise

TLDR
The results of this study provide the first evidence that an intact gut microbiome is necessary for skeletal muscle adaptation to exercise.

Resistance and Endurance Exercise Training Induce Differential Changes in Gut Microbiota Composition in Murine Models

TLDR
Interestingly, taxa associated with anti- and proinflammatory responses presented the same pattern after both models of exercise, and several taxa was differently related to maximal endurance or resistance performance, most of them did not respond to training.

Exercise Alters Gut Microbiota Composition and Function in Lean and Obese Humans

TLDR
It is suggested that exercise training induces compositional and functional changes in the human gut microbiota that are dependent on obesity status, independent of diet and contingent on the sustainment of exercise.

Altered gut microbiota by voluntary exercise induces high physical activity in high-fat diet mice

TLDR
The results suggest that exercise-induced high physical activity might be transmitted to un-exercised HFD mice via its altered gut microbiota.

Exercise training-induced modification of the gut microbiota persists after microbiota colonization and attenuates the response to chemically-induced colitis in gnotobiotic mice

TLDR
It is demonstrated that colonization of mice with a gut microbiota from exercise-trained mice led to an attenuated response to chemical colitis, evidenced by reduced colon shortening, attenuated mucus depletion and augmented expression of cytokines involved in tissue regeneration.

Different Exercise Intensity Associates with Varied Disease Biomarkers of Guts-Microbiome Genera Change in Rats: Preliminary Study

TLDR
It is found that the relative abundance in bacterial genera in Prevotella and Firmicutes/Bacteroidetes were significantly correlated with the experiment timepoints in different exercise intensities (Pearson’s correlation, P<0.05) compare to other genera.

Limited Effects of Low-to-Moderate Aerobic Exercise on the Gut Microbiota of Mice Subjected to a High-Fat Diet

TLDR
It is suggested that two months of low-to-moderate exercise does not achieve a preponderant modulatory effect on shaping microbiota when submitted to the high-fat diet.

Effect of voluntary wheel running on gut microbiota composition in developing mice.

TLDR
Gut microbiota be affected after short-term voluntary wheel running in developing mice, and there was a significant separation between the running group and the control group in beta diversity measures.

Intensive, prolonged exercise seemingly causes gut dysbiosis in female endurance runners

TLDR
The present work suggested that the gut microbiotas of female endurance runners are seemingly dysbiotic when compared with those of control subjects, and further investigation of the mechanism by which intensive, prolonged exercise affects the gut microbiota is recommended.

Effects of 12 weeks of resistance training on gut microbiota composition of rats.

TLDR
Improvements in the diversity and composition of the gut microbiota were identified in the RT group and suggest that RT has the potential to enhance the diversity of the microbiome and improve its biological functions.
...

References

SHOWING 1-10 OF 53 REFERENCES

Exercise Prevents Weight Gain and Alters the Gut Microbiota in a Mouse Model of High Fat Diet-Induced Obesity

TLDR
HF diet resulted in significantly greater body weight and adiposity as well as decreased glucose tolerance that were prevented by voluntary Ex (p<0.05) and Ex induces a unique shift in the gut microbiota that is different from dietary effects.

Diet and exercise orthogonally alter the gut microbiome and reveal independent associations with anxiety and cognition

BackgroundThe ingestion of a high-fat diet (HFD) and the resulting obese state can exert a multitude of stressors on the individual including anxiety and cognitive dysfunction. Though many studies

Structural modulation of gut microbiota in life-long calorie-restricted mice

TLDR
It is shown that life-long calorie restriction on both high-fat or low-fat diet, but not voluntary exercise, significantly changes the overall structure of the gut microbiota of C57BL/6 J mice, suggesting that animals under calorie restriction can establish a structurally balanced architecture of gut microbiota that may exert a health benefit to the host via reduction of antigen load from the gut.

Exercise and associated dietary extremes impact on gut microbial diversity

TLDR
Evidence is provided for a beneficial impact of exercise on gut microbiota diversity but also indicate that the relationship is complex and is related to accompanying dietary extremes.

Exercise Attenuates PCB-Induced Changes in the Mouse Gut Microbiome

TLDR
The results show that oral exposure to PCBs can induce substantial changes in the gut microbiome, which may then influence their systemic toxicity, which can be attenuated by behavioral factors, such as voluntary exercise.

Temporal stability of the mouse gut microbiota in relation to innate and adaptive immunity.

TLDR
It is suggested that CD45-regulated immune responses either are stimulated by the presence of bacteria per se or promote temporal stability by selecting for the occurrence of specific taxa.

Voluntary Running Exercise Alters Microbiota Composition and Increases n-Butyrate Concentration in the Rat Cecum

TLDR
The effects of voluntary wheel-running exercise on cecal microbiota and short-chain fatty acid production were investigated in rats and the exercised rats showed a significantly higher n-butyrate concentration than the sedentary rats.

Effect of Metformin on Metabolic Improvement and Gut Microbiota

TLDR
It is demonstrated that the gut microbiota and their metabolic pathways are influenced by metformin treatment, using a mouse model of high-fat-diet (HFD)-induced obesity with and without met formin treatment.
...