Voluntary alcohol consumption alters stress-induced changes in dopamine-2 receptor binding in Wistar-Kyoto rat brain.

@article{Yaroslavsky2010VoluntaryAC,
  title={Voluntary alcohol consumption alters stress-induced changes in dopamine-2 receptor binding in Wistar-Kyoto rat brain.},
  author={Irene Yaroslavsky and Shanaz M. Tejani-Butt},
  journal={Pharmacology, biochemistry, and behavior},
  year={2010},
  volume={94 3},
  pages={471-6}
}
The Wistar-Kyoto (WKY) rat has been proposed as an animal model of depressive behavior and exhibits hyper-responsiveness to stressful stimulation when compared to other rat strains. We have demonstrated that WKY rats consume 200% more alcohol under naïve conditions as compared to their outbred counterparts, Wistar (WIS) rats. The present study was designed to understand the influence of stress and alcohol consumption on central dopamine type-2 (D2) receptor sites in these two behaviorally… CONTINUE READING