Voluntary adolescent drinking enhances excitation by low levels of alcohol in a subset of dopaminergic neurons in the ventral tegmental area.

@article{Avegno2016VoluntaryAD,
  title={Voluntary adolescent drinking enhances excitation by low levels of alcohol in a subset of dopaminergic neurons in the ventral tegmental area.},
  author={Elizabeth M Avegno and Michael Charles Salling and Anders Borgkvist and Ana Mrejeru and Alexander C Whitebirch and Elyssa B. Margolis and David Sulzer and Neil L. Harrison},
  journal={Neuropharmacology},
  year={2016},
  volume={110 Pt A},
  pages={386-395}
}
Enhanced dopamine (DA) neurotransmission from the ventral tegmental area (VTA) to the ventral striatum is thought to drive drug self-administration and mediate positive reinforcement. We examined neuronal firing rates in slices of mouse midbrain following adolescent binge-like alcohol drinking and find that prior alcohol experience greatly enhanced the sensitivity to excitation by ethanol itself (10-50 mM) in a subset of ventral midbrain DA neurons located in the medial VTA. This enhanced… CONTINUE READING
4 Citations
46 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 46 references

Similar Papers

Loading similar papers…