Voluntary Ingestion of Cortinarius Mushrooms Leading to Chronic Interstitial Nephritis
@article{Calvio1998VoluntaryIO, title={Voluntary Ingestion of Cortinarius Mushrooms Leading to Chronic Interstitial Nephritis}, author={Jesus Calvi{\~n}o and Rafael Romero and Elena Pintos and Daniel Novoa and Dolores G{\"u}imil and Teresa Cordal and Javier Mardaras and V{\'i}ctor Petuya Arcocha and Xose M. Lens and Domingo S{\'a}nchez-Guisande}, journal={American Journal of Nephrology}, year={1998}, volume={18}, pages={565 - 569} }
‘Magic mushrooms’ ingestion among the drug-using population has become a popular cheap way to get hallucinogenic effects which is not free of complications. One of these is acute renal failure related to Cortinarius genus intake. This one greatly resembles ‘magic mushrooms’ and confusion is possible for inexperienced collectors. We report the case of a young male ex-drug addict who developed acute tubulointerstitial nephritis after voluntary ingestion of Cortinarius orellanus. The clinical…
26 Citations
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Three cases of acute renal failure in young men who ingested wild mushrooms with the intent of producing hallucinations are described and, in these cases, renal biopsy revealed tubulointerstitial nephritis and fibrosis.
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This work aims to review about Cortinarius species, including epidemiological studies, chemical structure, toxicokinetics, toxic doses, mechanisms of toxicity, diagnosis, prognosis, and treatment options.
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The incidence of acute renal failure varies from 30 to 46%, it depends on individual sensitivity, pre-existing nephropathy and the cumulated dose of toxin ingested, and early and severe interstitial fibrosis, marked interstitial oedema and tubular epithelial necrosis are the most characteristics renal lesions.
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Orellanine was almost exclusively eliminated by glomerular filtration as well as by peritoneal dialysis, and could be used as treatment for metastatic renal cancer.
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