Voluntary Ingestion of Cortinarius Mushrooms Leading to Chronic Interstitial Nephritis

@article{Calvio1998VoluntaryIO,
  title={Voluntary Ingestion of Cortinarius Mushrooms Leading to Chronic Interstitial Nephritis},
  author={Jesus Calvi{\~n}o and Rafael Romero and Elena Pintos and D. Novoa and Dolores G{\"u}imil and Teresa Cordal and Javier Mardaras and V{\'i}ctor Petuya Arcocha and Xose M. Lens and Domingo S{\'a}nchez-Guisande},
  journal={American Journal of Nephrology},
  year={1998},
  volume={18},
  pages={565 - 569}
}
‘Magic mushrooms’ ingestion among the drug-using population has become a popular cheap way to get hallucinogenic effects which is not free of complications. One of these is acute renal failure related to Cortinarius genus intake. This one greatly resembles ‘magic mushrooms’ and confusion is possible for inexperienced collectors. We report the case of a young male ex-drug addict who developed acute tubulointerstitial nephritis after voluntary ingestion of Cortinarius orellanus. The clinical… 
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Three cases of acute renal failure in young men who ingested wild mushrooms with the intent of producing hallucinations are described and, in these cases, renal biopsy revealed tubulointerstitial nephritis and fibrosis.
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This work aims to review about Cortinarius species, including epidemiological studies, chemical structure, toxicokinetics, toxic doses, mechanisms of toxicity, diagnosis, prognosis, and treatment options.
[Acute renal failure following ingestion of Cortinarius orellanus in 12 patients. Initial presentation and progress over a period of 13 years].
TLDR
The incidence of acute renal failure varies from 30 to 46%, it depends on individual sensitivity, pre-existing nephropathy and the cumulated dose of toxin ingested, and early and severe interstitial fibrosis, marked interstitial oedema and tubular epithelial necrosis are the most characteristics renal lesions.
Nephrotoxicity of over-the-counter analgesics, natural medicines, and illicit drugs.
  • D. Blowey
  • Medicine
    Adolescent medicine clinics
  • 2005
TLDR
The nephrotoxic effects of OTC analgesics, natural medicines, and illicit drugs are reviewed.
Main features of Cortinarius spp. poisoning: a literature review.
TLDR
Ingestion of Cortinarius species must be systematically suspected whenever tubulo-interstitial nephritis is diagnosed, especially as mushrooms may have been ingested 1-2 weeks before.
Natural medicines causing acute kidney injury.
TLDR
Physicians need to be aware of this condition to make a timely diagnosis and provide appropriate management and public awareness and regulation of the use of these medicines are required to eradicate this entity from the community.
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The current state of knowledge concerning renal injuries resulting from envenomation by coelenterates is summarized and the expected mechanisms, possibilities for therapeutic approaches, and strategies for preventing human diseases in future are described.
Nephropathy associated with animal, plant, and chemical toxins in the tropics.
TLDR
A high index of suspicion, careful history taking, and an awareness of local practices are essential for proper diagnosis and management of toxic nephropathies in the tropics.
Nephrotoxicity of Natural Products: Aristolochic Acid and Fungal Toxins
This article reviews the chemistry, toxicokinetics, and biological activities of natural nephrotoxins found in certain herbs used for medicinal purposes and in fungi associated with not only various
Pharmacokinetic Properties of the Nephrotoxin Orellanine in Rats
TLDR
Orellanine was almost exclusively eliminated by glomerular filtration as well as by peritoneal dialysis, and could be used as treatment for metastatic renal cancer.
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