Voluntary Exercise Preconditioning Activates Multiple Antiapoptotic Mechanisms and Improves Neurological Recovery after Experimental Traumatic Brain Injury.

@article{Zhao2015VoluntaryEP,
  title={Voluntary Exercise Preconditioning Activates Multiple Antiapoptotic Mechanisms and Improves Neurological Recovery after Experimental Traumatic Brain Injury.},
  author={Zaorui Zhao and Boris E Sabirzhanov and Junfang Wu and Alan I. Faden and Bogdan A Stoica},
  journal={Journal of neurotrauma},
  year={2015},
  volume={32 17},
  pages={1347-60}
}
Physical activity can attenuate neuronal loss, reduce neuroinflammation, and facilitate recovery after brain injury. However, little is known about the mechanisms of exercise-induced neuroprotection after traumatic brain injury (TBI) or its modulation of post-traumatic neuronal cell death. Voluntary exercise, using a running wheel, was conducted for 4 weeks immediately preceding (preconditioning) moderate-level controlled cortical impact (CCI), a well-established experimental TBI model in mice… CONTINUE READING

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In addition , exercise preconditioning activated the brain - derived neurotrophic factor pathway before trauma and amplified the injury - dependent increase in heat shock protein 70 expression , thus attenuating key apoptotic pathways .
However , little is known about the mechanisms of exercise - induced neuroprotection after traumatic brain injury ( TBI ) or its modulation of post - traumatic neuronal cell death .
However , little is known about the mechanisms of exercise - induced neuroprotection after traumatic brain injury ( TBI ) or its modulation of post - traumatic neuronal cell death .
However , little is known about the mechanisms of exercise - induced neuroprotection after traumatic brain injury ( TBI ) or its modulation of post - traumatic neuronal cell death .
However , little is known about the mechanisms of exercise - induced neuroprotection after traumatic brain injury ( TBI ) or its modulation of post - traumatic neuronal cell death .
However , little is known about the mechanisms of exercise - induced neuroprotection after traumatic brain injury ( TBI ) or its modulation of post - traumatic neuronal cell death .
However , little is known about the mechanisms of exercise - induced neuroprotection after traumatic brain injury ( TBI ) or its modulation of post - traumatic neuronal cell death .
However , little is known about the mechanisms of exercise - induced neuroprotection after traumatic brain injury ( TBI ) or its modulation of post - traumatic neuronal cell death .
However , little is known about the mechanisms of exercise - induced neuroprotection after traumatic brain injury ( TBI ) or its modulation of post - traumatic neuronal cell death .
However , little is known about the mechanisms of exercise - induced neuroprotection after traumatic brain injury ( TBI ) or its modulation of post - traumatic neuronal cell death .
In addition , exercise preconditioning activated the brain - derived neurotrophic factor pathway before trauma and amplified the injury - dependent increase in heat shock protein 70 expression , thus attenuating key apoptotic pathways .
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