Voluntary Exercise Positively Affects the Recovery of Long-Nerve Gap Injury Following Tube-Bridging with Human Skeletal Muscle-Derived Stem Cell Transplantation

@inproceedings{Seta2018VoluntaryEP,
  title={Voluntary Exercise Positively Affects the Recovery of Long-Nerve Gap Injury Following Tube-Bridging with Human Skeletal Muscle-Derived Stem Cell Transplantation},
  author={Hiroya Seta and Daisuke Maki and Akihito Kazuno and Ippei Yamato and Nobuyuki Nakajima and Shuichi Soeda and Yoshiyasu Uchiyama and Tetsuro Tamaki},
  booktitle={Journal of clinical medicine},
  year={2018}
}
The therapeutic effects of voluntary exercise on the recovery of long-gap nerve injury following the bridging of an acellular conduit filled with human skeletal muscle-derived stem cells (Sk-SCs) have been described. Human Sk-SCs were sorted as CD34⁺/45- (Sk-34) cells, then cultured/expanded under optimal conditions for 2 weeks. Surgery to generate a long-gap sciatic nerve injury was performed in athymic nude mice, after which the mice were divided into exercise (E) and non-exercise (NE) groups… CONTINUE READING