Volumetric characterization of sodium-induced G-quadruplex formation.

  title={Volumetric characterization of sodium-induced G-quadruplex formation.},
  author={Helen Y Fan and Yuen Lai Shek and Amir Parviz Khosravi Amiri and David N Dubins and Heiko Heerklotz and Robert B. Macgregor and Tigran V Chalikian},
  journal={Journal of the American Chemical Society},
  volume={133 12},
Oligodeoxyribonucleotides (ODN) with repeats of the human telomeric sequence can adopt different tetrahelical conformations that exhibit similar energetic parameters. We studied the volumetric properties of the folded and unfolded states of an ODN with four repeats of the human telomeric sequence, d[A(GGGTTA)(3)GGG], by combining pressure-perturbation… CONTINUE READING