Volume sensitive hypertension and the digoxin-like factor. Reversal by a Fab directed against digoxin in DOCA-salt hypertensive rats.

@article{Krep1995VolumeSH,
  title={Volume sensitive hypertension and the digoxin-like factor. Reversal by a Fab directed against digoxin in DOCA-salt hypertensive rats.},
  author={H H Krep and Deborah A. Price and P A Soszynski and Q F Tao and Steven W Graves and Norman Kenneth Hollenberg},
  journal={American journal of hypertension},
  year={1995},
  volume={8 9},
  pages={
          921-7
        }
}
Although volume and vasoconstriction have been considered polar elements in a useful pathogenetic hypertension model, many observations suggest that vasoconstriction is involved in volume-dependent hypertension, reflecting the effect of a digitalis-like factor. To examine that possibility, we assessed the depressor responses to Digibind, an antibody Fab directed against digoxin, in a volume-dependent model--DOCA-salt-induced hypertension in rats. Digibind (10 mg/kg, intravenously) induced a… CONTINUE READING

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