Volume sensitive efflux of taurine in HEK293 cells overexpressing phospholemman.

@article{MoralesMulia2000VolumeSE,
  title={Volume sensitive efflux of taurine in HEK293 cells overexpressing phospholemman.},
  author={M Morales-Mulia and H Pasantes-morales and Julio Mor{\'a}n},
  journal={Biochimica et biophysica acta},
  year={2000},
  volume={1496 2-3},
  pages={
          252-60
        }
}
The role of the phospholemman (PLM) on the efflux of taurine and chloride induced by swelling was studied in HEK293 cells overexpressing stable transfected PLM. PLM, a substrate for protein kinases C and A, is a protein that induces an anion current in Xenopus oocytes and forms taurine-selective channels in lipid bilayers. Taurine contributes as an osmolyte to regulatory volume decrease (RVD) and is highly permeable through PLM channels in bilayers. In PLM-overexpressing cells the process of… CONTINUE READING

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