Volume regulation in liver: further characterization by inhibitors and ionic substitutions.

@article{Hussinger1990VolumeRI,
  title={Volume regulation in liver: further characterization by inhibitors and ionic substitutions.},
  author={Dieter H{\"a}ussinger and Thomas Stehle and Florian Lang},
  journal={Hepatology},
  year={1990},
  volume={11 2},
  pages={243-54}
}
The present study has been performed to elucidate the mechanisms of volume regulation in isolated perfused liver. Reduction of extracellular osmolarity by 80 mOsm/L leads to a release of potassium and a sustained alkalinization of effluent. Reexposure to isotonic perfusate leads to reuptake of potassium by the liver and acidification of effluent. Part of the alkalinization could be due to release of bicarbonate parallel to potassium release. Carboanhydrase inhibition and replacement of… CONTINUE READING