Volume regulation in NIH/3T3 cells not expressing P-glycoprotein. II. Chloride and amino acid fluxes.

@article{Morn1997VolumeRI,
  title={Volume regulation in NIH/3T3 cells not expressing P-glycoprotein. II. Chloride and amino acid fluxes.},
  author={Julio Mor{\'a}n and Dante Miranda and Claudia Pe{\~n}a-Segura and Herminia Pasantes-Morales},
  journal={The American journal of physiology},
  year={1997},
  volume={272 6 Pt 1},
  pages={C1804-9}
}
The osmolyte function of amino acids and Cl in native NIH/3T3 cells not expressing the P-glycoprotein was examined by investigating the free amino acid concentration and the swelling-activated efflux of [3H]taurine, as representative of amino acids, and of 125I, as a tracer for Cl. Taurine and 125I efflux was activated by 20 and 30% hyposmotic solutions. At 50% hyposmotic solutions, the osmolyte pool was essentially depleted. The Cl channel blockers 5-nitro-2-(3-phenylpropyl-amino)benzoic acid… CONTINUE READING

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