Volume-regulated anion channel—a frenemy within the brain

@article{Mongin2015VolumeregulatedAC,
  title={Volume-regulated anion channel—a frenemy within the brain},
  author={Alexander A Mongin},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2015},
  volume={468},
  pages={421-441}
}
The volume-regulated anion channel (VRAC) is a ubiquitously expressed yet highly enigmatic member of the superfamily of chloride/anion channels. It is activated by cellular swelling and mediates regulatory cell volume decrease in a majority of vertebrate cells, including those in the central nervous system (CNS). In the brain, besides its crucial role in cellular volume regulation, VRAC is thought to play a part in cell proliferation, apoptosis, migration, and release of physiologically active… CONTINUE READING

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