Volume-regulated anion channel—a frenemy within the brain

  title={Volume-regulated anion channel—a frenemy within the brain},
  author={Alexander A Mongin},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
The volume-regulated anion channel (VRAC) is a ubiquitously expressed yet highly enigmatic member of the superfamily of chloride/anion channels. It is activated by cellular swelling and mediates regulatory cell volume decrease in a majority of vertebrate cells, including those in the central nervous system (CNS). In the brain, besides its crucial role in cellular volume regulation, VRAC is thought to play a part in cell proliferation, apoptosis, migration, and release of physiologically active… CONTINUE READING


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Patapoutian A (2014) SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion

  • Z Qiu, AE Dubin, +5 authors AP Orth
  • 2014
Highly Influential
4 Excerpts

Smallconductance Cl(-) channels contribute to volume regulation and phagocytosis in microglia

  • G Ducharme, EW Newell, C Pinto, LC Schlichter
  • Eur J Neurosci
  • 2007
Highly Influential
20 Excerpts

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