Volume of distribution terms for a drug (ceftriaxone) exhibiting concentration-dependent protein binding I. Theoretical considerations

@article{McNamara1983VolumeOD,
  title={Volume of distribution terms for a drug (ceftriaxone) exhibiting concentration-dependent protein binding I. Theoretical considerations},
  author={Patrick J McNamara and Milo Gibaldi and Klaus Stoeckel},
  journal={European Journal of Clinical Pharmacology},
  year={1983},
  volume={25},
  pages={399-405}
}
SummaryWe have theoretically examined the influence of plasma protein binding (specifically the fraction unbound, fp) on the pharmacokinetic parameters following rapid injection of a drug undergoing concentration-dependent binding. Particular emphasis was placed on the apparent volume of distribution terms based on both total and unbound drug concentrations. Computer simulations were performed to establish the validity and utility of such relationships. The following observations were made: a… CONTINUE READING

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