Volume of distribution at steady state for a linear pharmacokinetic system with peripheral elimination.

@article{Berezhkovskiy2004VolumeOD,
  title={Volume of distribution at steady state for a linear pharmacokinetic system with peripheral elimination.},
  author={Leonid M. Berezhkovskiy},
  journal={Journal of pharmaceutical sciences},
  year={2004},
  volume={93 6},
  pages={1628-40}
}
The problem of finding the steady-state volume of distribution V(ss) for a linear pharmacokinetic system with peripheral drug elimination is considered. A commonly used equation V(ss) = (D/AUC)*MRT is applicable only for the systems with central (plasma) drug elimination. The following equation, V(ss) = (D/AUC)*MRT(int), was obtained, where AUC is the commonly calculated area under the time curve of the total drug concentration in plasma after intravenous (iv) administration of bolus drug dose… CONTINUE READING