Volume matters: novel roles of the volume-regulated CLC-3 channels in hypertension-induced cerebrovascular remodeling.

The adaptive remodeling of cerebral arteries, including hypertrophy (medial thickening) and eutrophy (luminal narrowing), is a prominent feature of hypertension and a major risk factor for stroke.1–3 Multiple mechanisms, such as arterial smooth muscle cell (SMC) proliferation, migration and apoptosis, endothelial cell dysfunction, inflammation, and fibrosis… CONTINUE READING