Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia.

@article{Kaye1997VolumeLO,
  title={Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia.},
  author={Jeffrey A. Kaye and T Swihart and Diane B. Howieson and Alison Dame and Mindy Milar Moore and T Karnos and Richard Camicioli and Michele A. Ball and Barry S Oken and G. G. Sexton},
  journal={Neurology},
  year={1997},
  volume={48 5},
  pages={1297-304}
}
OBJECTIVE To determine initial locus and rate of degeneration of temporal lobe structures (total lobe, hippocampus and parahippocampus) in preclinical dementia. BACKGROUND Postmortem studies suggest that the earliest changes in Alzheimer's disease are neurofibrillary tangle formation in hippocampus and adjacent cortex. MRI volume analysis of temporal lobe structures over time in subjects prior to developing dementia may allow the identification of when these processes begin, the rate they… CONTINUE READING
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