Volume-activated chloride currents associated with the multidrug resistance P-glycoprotein.

  title={Volume-activated chloride currents associated with the multidrug resistance P-glycoprotein.},
  author={Christopher F. Higgins},
  journal={The Journal of physiology},
The ability to regulate volume is an important property of most, if not all cells. In epithelial cells, amongst others, cell volume-activated chloride channels are central to this response. The molecular identities of these channels are not yet known. Expression of the human multidrug resistance P-glycoprotein (P-gp) has been associated with cell volume-regulated chloride currents, although the nature of this association is the subject of debate. Recent data indicate that P-gp acts by… CONTINUE READING

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