Volume-activated chloride current is not related to P-glycoprotein overexpression.

  title={Volume-activated chloride current is not related to P-glycoprotein overexpression.},
  author={Yuetian Dong and Kevin G Chen and George E Duran and Keisuke Kouyama and Allen C. Chao and Branimir Sikic and Sastry V. R. S. Gollapudi and Satishkumar S Gupta and Phyllis L Gardner},
  journal={Cancer research},
  volume={54 19},
It has been suggested that P-glycoprotein (P-gp), an ATP-dependent transporter responsible for classical multidrug resistance, is also a volume-regulated chloride channel. We reexamined this hypothesis by use of whole-cell patch clamp recordings of three matched pairs of cell lines, which were either drug-sensitive or drug-resistant due to P-gp overexpression. We demonstrate here that volume-regulated chloride-selective currents can be induced in cells with or without P-gp expression… CONTINUE READING

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