Voltage-shift of the current activation in HERG S4 mutation (R534C) in LQT2.

  title={Voltage-shift of the current activation in HERG S4 mutation (R534C) in LQT2.},
  author={Toshiaki Nakajima and Tetsushi Furukawa and Yuji Hirano and Toshio Tanaka and Harumizu Sakurada and Toshiyuki Takahashi and Ryozo Nagai and Takehito Itoh and Yusuke Katayama and Yoshihiro Nakamura and Masayasu Hiraoka},
  journal={Cardiovascular research},
  volume={44 2},
OBJECTIVE Recently, a novel missense mutation (R534C) in the S4 region of human ether-a-go-go-related gene (HERG) was identified in one Japanese LQT2 family. The S4 region presumably functions as a voltage sensor. However, it has not yet been addressed whether the S4 region of HERG indeed functions as a voltage sensor, and whether these residues play any role in abnormal channel function in cardiac repolarization. METHODS We characterized the electrophysiological properties of the R534C… CONTINUE READING
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HERG current suppression by a shift in voltage dependence of activation:its role on QT prolongation examined by a computer simulation model [abstract

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2 Excerpts

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