Voltage-sensor activation with a tarantula toxin as cargo

  title={Voltage-sensor activation with a tarantula toxin as cargo},
  author={L. Revell Phillips and Mirela Milescu and Yingying Li-Smerin and Joseph A. Mindell and Jae Il Kim and Kenton Jon Swartz},
The opening and closing of voltage-activated Na+, Ca2+ and K+ (Kv) channels underlies electrical and chemical signalling throughout biology, yet the structural basis of voltage sensing is unknown. Hanatoxin is a tarantula toxin that inhibits Kv channels by binding to voltage-sensor paddles, crucial helix-turn-helix motifs within the voltage-sensing domains that are composed of S3b and S4 helices. The active surface of the toxin is amphipathic, and related toxins have been shown to partition… CONTINUE READING
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