Voltage-sensitive sodium channels: an evolving molecular view.

  title={Voltage-sensitive sodium channels: an evolving molecular view.},
  author={Robert L. Barchi and J M Casadei and Richard Gordon and Ross H. Roberts},
  journal={Society of General Physiologists series},
Sodium channel proteins have now been isolated from a number of nerve and muscle preparations. All are characterized by the presence of a very large glycoprotein subunit of approximately 260 kilodaltons which may contain the structural features required for voltage-dependent channel gating and cation selectivity. These purified proteins have been reconstituted into vesicle systems and planar bilayers and demonstrate the ensemble and single-channel behavior characteristic of the native sodium… CONTINUE READING

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