Voltage-sensitive gating induced by a mutation in the fifth transmembrane domain of CFTR.

A mutation in the fifth transmembrane domain of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel (V317E) resulted in whole cell currents that exhibited marked outward rectification on expression in Xenopus oocytes. However, the single-channel unitary current (i)-voltage (V) relationship failed to account for the rectification of… CONTINUE READING

Topics

Statistics

0100200300'04'06'08'10'12'14'16'18
Citations per Year

356 Citations

Semantic Scholar estimates that this publication has 356 citations based on the available data.

See our FAQ for additional information.