Voltage-sensing phosphatase modulation by a C2 domain

  title={Voltage-sensing phosphatase modulation by a C2 domain},
  author={Paul M. Castle and Kevin D. Zolman and Susy C Kohout},
  booktitle={Front. Pharmacol.},
The voltage-sensing phosphatase (VSP) is the first example of an enzyme controlled by changes in membrane potential. VSP has four distinct regions: the transmembrane voltage-sensing domain (VSD), the inter-domain linker, the cytosolic catalytic domain, and the C2 domain. The VSD transmits the changes in membrane potential through the inter-domain linker activating the catalytic domain which then dephosphorylates phosphatidylinositol phosphate (PIP) lipids. The role of the C2, however, has not… CONTINUE READING
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