Voltage-regulated water flux through aquaporin channels in silico.

  title={Voltage-regulated water flux through aquaporin channels in silico.},
  author={Jochen S. Hub and Camilo Aponte-Santamar{\'i}a and Helmut Grubm{\"u}ller and Bert L de Groot},
  journal={Biophysical journal},
  volume={99 12},
Aquaporins (AQPs) facilitate the passive flux of water across biological membranes in response to an osmotic pressure. A number of AQPs, for instance in plants and yeast, have been proposed to be regulated by phosphorylation, cation concentration, pH change, or membrane-mediated mechanical stress. Here we report an extensive set of molecular dynamics simulations of AQP1 and AQP4 subject to large membrane potentials in the range of ±1.5 V, suggesting that AQPs may in addition be regulated by an… CONTINUE READING