Voltage-induced gating of the mechanosensitive MscL ion channel reconstituted in a tethered lipid bilayer membrane.

@article{Andersson2008VoltageinducedGO,
  title={Voltage-induced gating of the mechanosensitive MscL ion channel reconstituted in a tethered lipid bilayer membrane.},
  author={Martin G I Andersson and George Onyango Okeyo and Danyell Wilson and Henk M Keizer and Paul C. Moe and Paul Blount and Daniel H Fine and Ananth Dodabalapur and Randolph S Duran},
  journal={Biosensors & bioelectronics},
  year={2008},
  volume={23 6},
  pages={919-23}
}
The mechanosensitive (MS) ion channel is gated by changes in bilayer deformation. It is functional without the presence of any other proteins and gating of the channel has been successfully achieved using conventional patch clamping techniques where a voltage has been applied together with a pressure over the membrane. Here, we have for the first time analyzed the large conducting (MscL) channel in a supported membrane using only an external electrical field. This was made possible using a… CONTINUE READING

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