Voltage gating in VDAC is markedly inhibited by micromolar quantities of aluminum

  title={Voltage gating in VDAC is markedly inhibited by micromolar quantities of aluminum},
  author={Eleanor Therese Dill and M. J. Holden and Marco Colombini},
  journal={The Journal of Membrane Biology},
The mitochondrial outer membrane contains voltagegated channels called VDAC that are responsible for the flux of metabolic substrates and metal ions across this membrane. The addition of micromolar quantities of aluminum chloride to phospholipid membranes containing VDAC channels greatly inhibits the voltage dependence of the channels' permeability. The channels remain in their high conducting (open) state even at high membrane potentials. An analysis of the change in the voltage-dependence… CONTINUE READING


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