Voltage-gated sodium channels in nociceptive versus non-nociceptive nodose vagal sensory neurons innervating guinea pig lungs.

@article{Kwong2008VoltagegatedSC,
  title={Voltage-gated sodium channels in nociceptive versus non-nociceptive nodose vagal sensory neurons innervating guinea pig lungs.},
  author={Kevin Kwong and Michael Carr and Anna Gibbard and Tony J Savage and Kuljit Singh and Junping Jing and Sonya N Meeker and B J Undem},
  journal={The Journal of physiology},
  year={2008},
  volume={586 5},
  pages={1321-36}
}
Lung vagal sensory fibres are broadly categorized as C fibres (nociceptors) and A fibres (non-nociceptive; rapidly and slowly adapting low-threshold stretch receptors). These afferent fibre types differ in degree of myelination, conduction velocity, neuropeptide content, sensitivity to chemical and mechanical stimuli, as well as evoked reflex responses. Recent studies in nociceptive fibres of the somatosensory system indicated that the tetrodotoxin-resistant (TTX-R) voltage-gated sodium… CONTINUE READING